Table 1. Causes of RP from different splicing factors.

Types of splicing factors	Causes of RP	References
PRPF3	Altered PRPF3 amino acids are highly conserved in all known PRPF3 orthologues	[5]
PRPF4	Haploinsufficiency and dominant-negative effects	[6]
PRPF6	Abnormal localization of endogenous PRPF6 within the nucleus	[7]
PRPF8	C-terminus exhibit a high degree of conservation	[8]
PRPF31	Incomplete penetrance; reduced levels of gene expression from the mutated allele	[9]–[12]
PR9	Proliferation and migration were decreased; FSCN2 and BBS2 were down-regulated in the mutated cells; pre-mRNA splicing of the FSCN2 gene was markedly affected	[13]–[14]
SNRNP200	A defect in hBrr2-dependent RNA unwinding and a consequent defect in spliceosome activation	[15]

PRPF3: Pre-mRNA processing factor 3; PR9: Pre-mRNA 9; SNRNP200: Small nuclear ribonucleoprotein particle 200; FSCN2: Fascin actin-bunding protein 2; BBS2: Bardet-biedl syndrome 2; RP: Retinitis pigmentosa.