European Society of Cardiology 1995 INR range	British Society of Haematology 1998 INR target
Mechanical valves*
Aortic:
First generation	3.0-4.5	3.5
Second generation	2.5-3.0	3.5†
Third generation	2.5-3.0	3.5†
Mitral	3.0-3.5	3.5
Bioprosthetic valves
In sinus rhythm:
Aortic	2.5-3.0 for three months	No anticoagulation‡
Mitral	3.0-3.5 for three months. No anticoagulation after three months	2.5 for three months. No anticoagulation after three months
In atrial fibrillation:
Rheumatic valvar heart disease	3.0-4.5	2.5
Patients with recurrent emboli under adequate anticoagulation	3.0-4.5 + 100 mg aspirin	—
Non-valvar atrial fibrillation with risk factors	2.0-3.0	2.5