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. 2024 Jul 1;15:1397049. doi: 10.3389/fphys.2024.1397049

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Copyright © 2024 Marrow, Alshamali, Edgett, Allwood, Cochrane, Al-Sabbag, Ayoub, Ask, Hare, Brunt and Simpson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pan-VEGFR inhibition via 8 days of axitinib treatment (i.p.) significantly upregulated left ventricular Epo RNA expression in EPO^fl/fl mice independent of erythropoiesis. (A) Saphenous hemoglobin levels and (B) left ventricle Epo RNA expression by qPCR in EPO^fl/fl compared to EPO^fl/fl+AXI mice. Data are expressed as mean ± SD and were considered significant when p < 0.05 as determined by unpaired, two-tailed t-test.