TABLE 4.
Ex vivo cardiac assessment using Langendorff isolated heart preparation. LVP, left ventricle systolic pressure; LV EDP, left ventricle end diastolic pressure. Data is presented as mean ± SEM.
| EPOfl/fl (n = 8) | EPOΔ/Δ (n = 8) | p-value | |
|---|---|---|---|
| Intrinsic Heart Rate (bpm) | 203 ± 25 | 342 ± 26* | 0.002 |
| LVP (mmHg) | 86 ± 3 | 96 ± 2* | 0.006 |
| LV EDP (mmHg) | 7 ± 1 | 7 ± 0 | 0.30 |
| Developed Pressure (mmHg) | 79 ± 3 | 89 ± 2* | 0.014 |
| dP/dt max (mmHg/s) | 3128 ± 166 | 3626 ± 135* | 0.04 |
| dP/dt min (mmHg/s) | −1978 ± 108 | −2488 ± 82* | 0.003 |
| % Recovery LVP | 27 ± 8 | 71 ± 2* | 0.0001 |
| % Recovery dP/dt max | 28 ± 9 | 76 ± 3* | <0.0001 |
| % Recovery dP/dt min | 24 ± 7 | 61 ± 3* | 0.0002 |
Significance was considered when p < 0.05 compared to EPOfl/fl (determined by an unpaired, two-tailed t-test and shown using bolded values and "*").