FIGURE 3.

Predicted and observed plasma concentration–time profiles for enzyme‐mediated DDIs with dasatinib acting as victim (a, b) and perpetrator drug (c, d). The solid lines show predicted geometric mean concentration–time profiles with (colored) and without (gray) intake of the perpetrator drug and ribbons show the corresponding geometric standard deviation of the population simulations (n = 100). Points depict mean observed data with corresponding standard deviation of dasatinib, while squares and triangles depict the observed data with corresponding standard deviation of simvastatin lactone and simvastatin acid, respectively. Predicted and observed plasma concentration–time profiles of all studies on a semilogarithmic scale are shown in Section S3.2.1. DDIs, drug–drug interactions; n, number of participants.