FIGURE 4.

Predicted and observed plasma concentration–time profiles of dasatinib for the pH‐dependent DDIs. The solid lines show predicted geometric mean concentration–time profiles with (colored) and without (gray) the intake of the perpetrator drug and ribbons show the corresponding geometric standard deviation of the population simulations (n = 100). Points depict mean observed data with corresponding standard deviation of dasatinib (if depicted in the respective publication). Predicted and observed plasma concentration–time profiles of all studies on a semilogarithmic scale are shown in Section S3.2.2. BHCl, betaine hydrochloride; DDIs, drug–drug interactions; n, number of participants.