TABLE 1.
Baseline characteristics of the 538 patients included depending on their vital status at D28. The median and interquartile range is given for continuous covariates, and the percentage is given for categorical covariates.
| Alive, N = 425 | Dead, N = 94 | Censored, N = 19 | Overall population, N = 538 | Missing | |
|---|---|---|---|---|---|
| Continuous covariates – Median [Q1;Q3] | |||||
| Age (years) | 64 [54;70] | 71 [64;78] | 72 [57;74] | 65 [56;72] | 0 |
| Weight (kg) | 85 [74;97] | 80 [70;91] | 80 [68;90] | 84 [73;96] | 1 |
| Height (cm) | 170 [165;176] | 170 [164;174] | 168 [160;177] | 170 [164;176] | 6 |
| BMI (kg/m2) | 29 [26;33] | 28 [25;31] | 28 [27;33] | 29 [26;33] | 6 |
| Charlson index | 2 [1;2] | 3 [1;4] | 1 [1;2] | 2 [1;3] | 0 |
| Time between first symptoms and ICU admission (days) | 9 [7;11] | 7 [4;9] | 10 [3;11] | 9 [6;11] | 10 |
| Length of hospital stay (days) | 19 [11;41] | 14 [8;21] | 10 [8;16] | 18 [11;34] | 5 |
| Length of ICU stay (days) | 8 [4;21] | 12 [7;19] | 7 [3;10] | 9 [5;20] | 1 |
| SOFA score | 2 [1;4] | 4 [2;7] | 1 [0;4.5] | 3 [1;5] | 0 |
| SAPSII score | 30 [22;37] | 38 [30;47] | 30 [22;44] | 31 [24;40] | 0 |
| Glasgow coma scale | 15 [15;15] | 15 [15;15] | 15 [14.5;15] | 15 [15;15] | 1 |
| Categorical covariates – n (%) | |||||
| Male gender | 298 (70) | 75 (80) | 19 (53) | 383 (71) | 0 |
| Mechanical ventilation before 3rd day in ICU | 122 (29) | 45 (48) | 6 (32) | 173 (32) | 0 |
| Mac Cabe index | 209 | ||||
| Stage 1 a | 1 (0.4) | 3 (5.3) | 0 (0) | 4 (1) | |
| Stage 2 b | 20 (7.6) | 10 (18) | 2 (25) | 32 (10) | |
| Stage 3 c | 243 (92) | 44 (77) | 6 (75) | 293 (89) | |
| Preexisting immunological disease | 32 (7.5) | 17 (18) | 0 (0) | 49 (9) | 0 |
| Treatment by ARA II d | 59 (14) | 15 (16) | 2 (11) | 76 (14) | 0 |
| Origin | 0 | ||||
| Exterior | 260 (61) | 60 (64) | 12 (63) | 332 (62) | |
| COVID unit | 75 (18) | 8 (9) | 1 (5) | 84 (16) | |
| Hospital e | 76 (18) | 24 (26) | 6 (32) | 106 (20) | |
| Other | 14 (3) | 2 (2) | 0 (0) | 16 (3) | |
| ARDS f | 165 (41) | 69 (78) | 8 (42) | 242 (47) | 26 |
| Nosocomial infections | 117 (32) | 45 (57) | 5 (26) | 167 (36) | 79 |
| Vital status at day 90 | |||||
| Alive | 353 (93) | 0 (0) | 0 (0) | 353 (74) | 64 |
| Dead | 27 (7) | 94 (100) | 0 (0) | 121 (26) | |
| COVID wave g | 0 | ||||
| 1 | 51 (12) | 16 (17) | 0 (0) | 67 (12) | |
| 2 | 142 (33) | 36 (38) | 8 (42) | 186 (35) | |
| 3 | 142 (33) | 21 (22) | 9 (47) | 172 (32) | |
| 4 | 90 (21) | 21 (22) | 2 (11) | 113 (21) | |
a
Disease deadly within a year.
b
Life threatening disease at 5 years.
c
No threatening disease.
d
Angiotensin II Receptor Antagonist.
e
Except COVID unit.
f
Acute Respiratory Distress Syndrome.
g
COVID wave: 1: from March 2020 to July 5th 2020. 2: from July 6th 2020 to January 3rd 2021. 3: from January 4th 2021 to July 4th 2021. 4: after July 5th 2021.