TABLE 2.

Bayesian information criterion (BIC) of the selected univariate joint model for each biomarker and those same models with no link between the different biomarkers and survival. The lowest BIC is indicated in bold.

Biomarker	Structural model	Link function	Association (${\beta }^s\ne 0$)	No association (${\beta }^s=0)$
HLA‐DR	Stein Fojo	Current value	6273	6280
CD4+ lymphocytes	Linear regression	Current value	6659	6657
CD8+ lymphocytes	Linear regression	Slope	6470	6465
CD4+/CD8+		Slope	41,729	41,724
Neutrophils	Bateman	Current value
Lymphocytes	Linear regression	Slope
Neutrophils/Lymphocytes		Current value	12,499	12,497

Note: The instantaneous risk of death is modeled as $h_i^s\left(t|{\mathrm{\Phi }}_i\right)=\frac{1}{\lambda }{e}^{{\beta }^s{\nu }^s\left(t\right|{\mathrm{\Phi }}_i)}$ with $\lambda$ the median length of survival, ${\nu }^s$ the link function of the structural longitudinal model and ${\beta }^s$ the association coefficient between the longitudinal and the survival parts of the model.