Figure 3.

Adult nephrin-Y3F mice show normal glucose tolerance. (A-B) OGTTs were performed using 2 mg of D-glucose per gram of bodyweight on 6-hour-fasted male (A; n = 8-9) or female (B; n = 5-6) WT or nephrin-Y3F mice (8 months of age). (C) AUC measurements for the respective OGTT curves in (A) and (B). (D) 6-hour fasting blood glucose concentrations on WT or nephrin-Y3F mice (n = 5-9) (8 months of age). Bars show mean ± SEM. Statistical significance was determined using 2-way ANOVA with a post hoc Tukey's test. Significant main effects differences are indicated as †† for P < .01.

Abbreviations: AUC, area under the curve; OGTT, oral glucose tolerance test; WT, wild-type.