TABLE 7.

Summary of toxicokinetic studies on TBBPA and TBBPA‐bDiBPrE addressing elimination reported in the previous Opinion (EFSA CONTAM Panel, 2011c) and studies identified since then.

Dose(s) tested	Route of exposure	Excretion route	% of retention/half‐life	Species	Reference
TBBPA
7 mg/kg bw of [14C]‐TBBPA	Gavage	Faeces (99%) at 72 h	19.9 h in the blood, 70.8 h in fat, 17.1 h in kidneys, 10.8 h in the liver, 39.3 h in the spleen, 48.0 h in muscle, 60.5 h in the gonads	Sprague–Dawley rats	Brady (1979) (as cited in WHO/IPCS, 1995)
2 mg/kg bw of [14C]‐TBBPA	Gavage	Faeces (99%) Urine (1%)	90% of the dose excreted after 72 h	Cannulated male Sprague–Dawley rats	Hakk et al. (2000)
250 or 1000 mg/kg bw of [14C]‐TBBPA	ip	Faeces (51%–65%) at 72 h	230 h in blood	Wistar rats	Szymańska et al. (2001)
5 mg/kg bw of [14C]‐TBBPA	Gavage (GD10‐GD16)	Faeces (99%) Urine (1%)	90% of the dose excreted after 72 h	Pregnant Wistar rats	Meerts et al. (1999)
300 mg/kg bw TBBPA	Gavage	Only urine was measured	13 h	Male Sprague–Dawley rats	Schauer et al. (2006)
2, 20, 200 mg/kg bw [14C]‐TBBPA	Oral/iv	Faeces (> 99%) Urine (< 1%)	983 min	Male Fischer‐344 rats	Kuester et al. (2007)
25, 250, 1000 mg/kg bw [14C]‐TBBPA	Oral/iv	Faeces (> 99%) Urine (< 1%)	155 min	Female Crl:WI (Han) rats	Knudsen et al. (2014)
25 mg/kg bw [14C]‐TBBPA	Gavage	NR	17 h	Wistar Han IGS rats dams and pups	Knudsen et al. (2018)
100 μg dissolved in 0.1 mL of corn oil	Gavage	Faeces (71%) at 24 h	12h	C57BL/6 mice dams	Nakao et al. (2022)
TBBPA derivatives
20 mg/kg bw of [14C]‐TBBPA‐bDiBPrE	Oral/iv	Faeces (95% of dose by 96 h)	13.9 h	Male Fischer‐344 rats	Knudsen et al. (2007)

Abbreviations: ip, intraperitoneal; iv, intravenous.