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. 2024 Jul 15;22(7):e8859. doi: 10.2903/j.efsa.2024.8859

TABLE C1.

Concentration of TBBPA in human samples from non‐European countries.

Country year Number of samples Concentration (ng/g lipid) Comments Reference
Human milk

Japan

2005–2006

n = 9

Mean, median (range) (MB):

1.04, 0.72 (0.39–2.22)

Fujii, Nishimura, et al. (2014)

Japan

2008–2010

n = 64

Mean, median (range):

48, 3.2 (< 0.0–2200)

Detected in 97% of the samples analysed Fujii et al. (2018)

Japan

2011–2013

n = 12

Mean (range):

0.0644 (0.00674–1.28) ng/mL

Akiyama et al. (2015)

Japan

2012–2013

n = 19

Mean (Range):

1.9 (< 0.018–8.7)

Nakao et al. (2015)

China

2011

n = 103

Mean, median (range):

0.41, 0.10 (< LOD‐12.46)

Detected in 53% of the samples Shi et al. (2013)

China

2011

n = 29 pooled samples

Mean, median (range):

7.58, 1.21 (0.14–66.8)

Detected in all pools analysed Shi et al. (2017a)

China

2014

n = 111

(from 37 mothers)

Mean, median (range):

5.59, 1.57 (< LOD‐42)

Detected in 64% of the samples analysed Huang et al. (2020)

China

2018

n = 105

Mean, median (range):

0.761, 0.271 (< LOD–34.8)

Detected in 99% of the samples analysed Zhao and Shi (2021)

USA

2004–2005

n = 43

Range:

< 0.03–0.550

Detected in 35% of the samples Carignan et al. (2012)
Serum

Republic of Korea

NR

n = 26

Congenital hypothyroidism mother‐infant pairs

n = 12 mother‐infant pairs w/o congenital hypothyroidism

Mean (range):

With congenital hypothyroidism:

Infants: 83 (< LOD–713)

Mothers: 8.61 (< LOD–48.25)

w/o congenital hypothyroidism:

Infants: 72.5 (< LOD–457.4)

Mothers: 10.7 (< LOD–74.0)

Kim and Oh (2014)

Japan

1989–1999

2010

n = 60

Adult males

Range:

Years 1989–1999:

< 50–950 pg/g ww

Year 2010:

< 50–420 pg/g ww

Detected in 28% of the samples analysed Fujii, Harada, et al. (2014)

Japan

2006

n = 10

Adult females

Mean, median (range):

40.5, 1.0 (< LOQ–238) pg/g ww

Fujii, Nishimura, et al. (2014)

China

2016

n = 181

Pregnant women

Median (range):

< LOD (< LOD–5.83) ng/mL

Detected in 30% of the samples analysed Li et al. (2020)

USA

2009

n = 12

Male firefighters after exposure to fire event

ND Shaw et al. (2013)
Adipose tissue

USA

NR

n = 24

Adults with and w/o Alzheimer disease (post‐mortem)

Median (P25–P75):

0.67 (0.51–0.91) ng/g ww

Manivannan et al. (2019)
Liver

USA

NR

n = 24

Adults with and w/o Alzheimer disease (post‐mortem)

Median (P25–P75):

1.85 (1.13–4.32) ng/g ww

Manivannan et al. (2019)
Urine

USA

2006–2010

n = 302

Women with breast cancer

ND Ilozumba et al. (2022)

China

NR

n = 10 adults from e‐waste area

n = 10 adults from non e‐waste area

ND Lin et al. (2020)

China

2020

n = 120 Wuxi population

n = 121 Taishun population

Males and females (3–86 years old)

ND

Geometric mean:

0.122 ng/mL

Detected in 4.2% of the samples analysed

Wei et al. (2022)

China

2020

n = 86 Chengdu population

n = 104 Nantong population

n = Shehong population

Mean (range):

4.41 (< 0.193–33.7)

0.140 (< 0.193–0.500)

0.135 (< 0.193–0.136)

Detected in 44.2% of the samples analysed

Detected in 2.88% of the samples analysed

Detected in 0.909% of the samples analysed

Xu, Hu, et al. (2022)

China

2013

n = 94

Individuals residing near a bisphenol AF manufacturing plant

ND Yang et al. (2014)

China

NR

n = 20 parent–child pairs

Average:

Children:

0.171 μg/L

Parents:

0.181 μg/L

Detected in 80% of the samples analysed in both groups Zhang et al. (2016)

China

NR

n = 1157 male and females general population (< 18–> 59 years old)

Mean (range):

0.04 (< 0.061–2.25) μg/L

Detected in 7.3% of the samples analysed Huang et al. (2023)
Hair

Republic of Korea, Iran

2017

n = 24 Korea

n = 15 Iran

Mean (range):

Korea: 5.00 (ND–16.04) ng/g

Iran: 0.23 (ND–1.08) ng/g

HBCDDs Barghi et al. (2018)

China

2019–2020

n = 598 (362 females and 236 males, average age of 62.6 ± 11.9 years old)

Range: < LOD ~ 1299 ng/g

Median: 1.86 ng/g

Significant higher concentrations of TBBPA in female hair than in male hair

Detected in 75% of the samples analysed Li et al. (2024)