TABLE 1.
Transformation by recombinant viruses in vitro and pathogenesis in infected cottontop tamarins
| Virus strain or mutant | Species and/or cell type | In vitro transformation experiments (no. positive/total)a | Pathogenesis (survival time in days)b |
|---|---|---|---|
| C488 | Human CBL | 8/13 | NA |
| C. jacchus PBMC | 9/9 | ND | |
| S. oedipus PBMC | 10/10 | 15 | |
| C488ΔFLIP | Human CBL | 7/13 | NA |
| C. jacchus PBMC | 9/9 | ND | |
| S. oedipus PBMC | 10/10 | 14, 15 |
a
Performed with human CBL (13 donors) and PBMC from C. jacchus (5 donors) and S. oedipus (10 donors). Parallel cultures of cells were infected with herpesvirus saimiri C488 or C488ΔFLIP.
b
NA, not applicable; ND, not done.