Fig. 1.

Altered TP53 and MYC genes are present in TNBC tumors and reduce Drosophila survival. (A) Hierarchical clustering of TNBC primary tumors as listed in TCGA, based on CNA and mutation of putative driver genes. CNAs are shown in order of genomic location, mutated putative driver genes are listed in alphabetical order. Overall survival of each patient is shown coded at the left, with white representing the longest and black the shortest survival. n=72. (B) Heads of GMR>w (control) and GMR>p53lh;Myc flies. Eyes were enlarged when targeted by Myc overexpression plus p53 knockdown (p53^lh; long hairpin). (C) Quantification of survival (shown as percent eclosion) of Myc-expressing flies in the presence (ptc>w and ptc>Myc) and absence (ptc>p53^sh and ptc>Myc p53^sh) of p53 knockdown (p53^sh; short hairpin). Kruskal–Wallis test: P<0.0001. n=14. Error bars represent the +standard error of the mean (+s.e.m.) and do not reflect the paired nature of the data. Other P-values: Wilcoxon test. See also Fig. S1 and Table S2.