Table 5. Antiproliferative Activities of Selected Leads against MYC-Driven Cancer Cell Lines.
| IC50/μMa |
|||
|---|---|---|---|
| cancer lineage | cell lines | 4m | 4o |
| Hematopoietic (leukemia, lymphoma) | RAJI | 0.71 ± 0.10 | 1.52 ± 0.53 |
| RAMOS | 1.06 ± 0.14 | 1.51 ± 0.42 | |
| SUDHL4 | 1.43 ± 0.24 | 2.20 ± 0.26 | |
| HL-60 | 3.03 ± 0.77 | 5.32 ± 0.76 | |
| Solid tumor (lung cancer) | H1299 | 3.70 ± 0.10 | 7.40 ± 2.00 |
IC50 values represent the mean ± SD of three independent experiments.