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. 2024 Jul 1;15(7):1143–1150. doi: 10.1021/acsmedchemlett.4c00220

Table 5. Antiproliferative Activities of Selected Leads against MYC-Driven Cancer Cell Lines.

    IC50/μMa
cancer lineage cell lines 4m 4o
Hematopoietic (leukemia, lymphoma) RAJI 0.71 ± 0.10 1.52 ± 0.53
  RAMOS 1.06 ± 0.14 1.51 ± 0.42
  SUDHL4 1.43 ± 0.24 2.20 ± 0.26
  HL-60 3.03 ± 0.77 5.32 ± 0.76
Solid tumor (lung cancer) H1299 3.70 ± 0.10 7.40 ± 2.00
a

IC50 values represent the mean ± SD of three independent experiments.