TABLE 2.

Change (per year) in T‐tau, P‐tau 181, Aβ42, SBP (systolic blood pressure), and DBP (diastolic blood pressure) in three groups (normotensive, controlled hypertension, and uncontrolled hypertension).

	Normotension (n = 134)	Controlled hypertension (n = 36)	Uncontrolled hypertension (n = 35)
Log T‐tau	0.02 (0.02 to 0.03), p < 0.001	0.02 (−0.00 to 0.05), p = 0.06	0.05 (0.03 to 0.07), p  < 0.001
T‐tau	5.7 (3.1 to 8.2), p < 0.001	6.1 (−0.6 to 12.9), p = 0.076	12.2 (7.2 to 17.3), p  < 0.001
Log P‐tau 181	0.02 (0.01 to 0.02), p < 0.001	0.02 (−0.00 to 0.03), p = 0.06	0.04 (0.03 to 0.03), p  < 0.001
P‐tau 181	0.71 (0.39 to 1.03), p < 0.001	0.42 (−0.39 to 1.24), p = 0.31	1.67 (1.04 to 2.29), p  < 0.001
Aβ42	1.57 (−6.57 to 9.69), p = 0.70	9.97 (−9.18 to 29.14), p = 0.31	−9.76 (−25.65 to 6.13), p = 0.23
SBP a	0.44 (−0.19 to 1.07), p = 0.17	−0.73 (−2.32 to 0.87), p = 0.37	−3.42 (−4.63 to −2.21), p  < 0.001
DBP a	−0.15 (−0.79 to 0.50), p = 0.66	−0.28 (−1.76 to 1.19), p = 0.71	−3.26 (−4.49 to −2.03), p  < 0.001

Note: Respective p values for slopes (change with time) are derived from mixed models for repeated measures. CSF biomarker or BP were dependent variables, and time, group, and group × time interaction were predictors. Age at baseline was added as covariate in all the models. Parentheses indicate 95% CI for slopes. Due to adjustment for multiple comparisons, slopes were considered significantly different from 0 at p < 0.016 (bolded in table). The group × time interaction term for log‐transformed T‐tau was p = 0.045 and for P‐tau 181 p = 0.019. The group × time interaction term for untransformed T‐tau was p = 0.075 and for P‐tau 181 p = 0.017. Both for SBP and DBP the group × time interaction was significant at p < 0.001. No significant interaction was found for Aβ42.Abbreviations: DBP, diastolic blood pressure; SBP, systolic blood pressure.

Significant p values are in bold.

^aData for 191 subjects.