TABLE 4.

Relationships between change in SBP (systolic blood pressure) and change in CSF biomarkers in three study subgroups (n = 191).

	Normotension (n = 125)	Controlled hypertension (n = 34)	Uncontrolled hypertension (n = 32)
Log T‐tau	0.001 (−0.001 to 0.003), p = 0.34	−0.001 (−0.005 to 0.003), p = 0.76	−0.004 (−0.007 to −0.002), p  = 0.001
T‐tau	0.51 (−0.16 to 1.17), p = 0.14	−0.50 (−1.71 to 0.71), p = 0.41	−1.03 (−1.76 to (−0.30), p  = 0.01
Log P‐tau 181	−0.001 (−0.003 to 0.001), p = 0.22	0.000 (−0.003 to 0.003), p = 0.99	−0.002 (−0.005 to 0.000), p = 0.03
P‐tau 181	−0.07 (−0.16 to 0.02), p = 0.13	0.03 (−0.14 to 0.20), p = 0.71	−0.11 (−0.22 to −0.01), p = 0.03
Aβ42	−0.35 (−1.96 to 1.25), p = 0.67	−0.94 (−3.82 to 1.94), p = 0.52	−0.39 (−2.21 to 1.44), p = 0.68

Note: Respective p values for slopes (change in biomarker with changes in SBP) are derived from mixed models for repeated measures. Biomarker was a dependent variable and SBP, group, and group × SBP interaction were predictors. Age at baseline was added as covariate in all models. Parentheses indicate 95% CI for slopes. Due to adjustment for multiple comparisons, slopes were considered significantly different from 0 at p < 0.016 (bolded in table). The group × SBP interaction term for both log transformed and untransformed T‐tau was p = 0.009.