. 2024 May 29;20(7):4389–4400. doi: 10.1002/alz.13800

TABLE 5.

Relationships between change in DBP (diastolic blood pressure) and change in CSF biomarkers in three study subgroups (n = 191).

	Normotension (n = 125)	Controlled hypertension (n = 34)	Uncontrolled hypertension (n = 32)
T‐tau	−0.72 (−1.72 to 0.27), p = 0.15	−1.08 (−2.78 to 0.61), p = 0.21	−1.34 (−2.55 to −0.11), p = 0.03
P‐tau 181	−0.14 (−0.25 to −0.03), p = 0.016	−0.03 (−0.21 to 0.16), p = 0.80	−0.30 (−0.44 to −0.16), p < 0.001
Aβ42	0.12 (−2.06 to 2.30), p = 0.91	1.43 (−2.15 to 5.01), p = 0.43	0.89 (−1.71 to 3.48), p = 0.50

Normotension

(n = 125)

Controlled hypertension

(n = 34)

Uncontrolled hypertension

(n = 32)

T‐tau

−0.72 (−1.72 to 0.27), p = 0.15

−1.08 (−2.78 to 0.61), p = 0.21

−1.34 (−2.55 to −0.11), p = 0.03

P‐tau 181

−0.14 (−0.25 to −0.03), p = 0.016

−0.03 (−0.21 to 0.16), p = 0.80

−0.30 (−0.44 to −0.16), p < 0.001

Aβ42

0.12 (−2.06 to 2.30), p = 0.91

1.43 (−2.15 to 5.01), p = 0.43

0.89 (−1.71 to 3.48), p = 0.50

Note: Respective p values for slopes (change in biomarker with changes in DBP) are derived from mixed models for repeated measures. Biomarker was a dependent variable and DBP, group, and group × DBP interaction were predictors. Age at baseline was added as covariate in all models. Parentheses indicate 95% CI for slopes. Due to adjustment for multiple comparisons, slopes were considered significantly different from 0 at p < 0.016 (bolded in table). The group × DBP interaction term for P‐tau 181 was p = 0.06.