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. 2024 Jul 15;22:363. doi: 10.1186/s12964-024-01740-5

Table 3.

Compotision of basal medium and expansion medium

Basal medium (DMEM/F12)
Product Company Product number Final concentration
DMEM/Ham's F–12 Gibco 12634–010
Pencillin–streptomycin Gibco 15140–122
HEPES Nacalai Tesque 17557–94 10 mM
Glutamax Gibco 35050–06 2 mM
Expansion medium (ExM)
Product Company Product number Final concentration
Basal medium 46.60%
B27 Supplement (50×) Gibco 2389219 2%
N–acetylcysteine Wako 015–05132 1 mM
Recombinant Human FGF10 Peprotech 100–26 10 ng/ml
Nicotinamide Wako 141–01202 10 mM
A83–01 Nacalai Tesque 19692–54 500 nM
SB202190 Sigma S7067 10 µM
Y–27632 Wako 034–24024 10 µM
Recombinant EGF Peprotech 100–15 50 ng/ml
Primocin InvivoGen ant–pm 50 µg/ml
Afamin Wnt3A* 50%

*We used L-WRN cell culture supernatant containing Wnt3a, R-spondin, and Noggin [39][40]