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. 2024 Jul 15;25:185. doi: 10.1186/s13059-024-03307-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Cattle CoRSIVs are enriched at transcription start sites and associated with genetic variation. A Manhattan plot of systemic interindividual variation index (SIVI) for all genomic blocks with ≥ 5 CpGs. Blocks with SIVI ≥ 20 (dashed line) are considered CoRSIVs. B The overlap of CoRSIVs / controls with transcription start sites (TSS), transcription end site (TES), gene body, and intergenic regions. CoRSIVs are enriched at TSS. C The overlap with genetic variants in 1 kb windows centered on CoRSIVs / control regions. D CoRSIV-flanking regions (± 50 kb at 5 kb increments) show overlap with various classes of transposable elements, specifically LINE-1 and LTR elements. Column to the left of 0 KB mark shows direct overlap of CoRSIVs with transposable elements