Table 9.
Linear regression analysis of annual change in CDR-SB score involving 100 patients with complete data, including APOE ɛ4-carrier status.
| Unadjusted | Adjusted model 1 | Adjusted model 2 | ||||
|---|---|---|---|---|---|---|
| β (SE) | p | β (SE) | p | β (SE) | p | |
| Age | 0.33 (0.001) | 0.004 | 0.17 (0.001) | 0.168 | 0.14 (0.001) | 0.245 |
| Sex | −0.42 (0.013) | 0.677 | −0.05 (0.012) | 0.596 | −0.04 (0.011) | 0.644 |
| Education | −0.16 (0.002) | 0.119 | −0.06 (0.002) | 0.553 | ||
| Whole brain volume | −0.27 (0.002) | 0.006 | −0.23 (0.002) | 0.062 | −0.24 (0.002) | 0.043 |
| MMSE-NR score | −0.25 (0.003) | 0.011 | −0.28 (0.003) | 0.004 | ||
| Follow-up time | 0.26 (<0.000) | 0.011 | 0.31 (0.000) | 0.003 | 0.26 (0.00) | 0.007 |
| MRI NQ before 2015 | 0.12 (0.013) | 0.236 | ||||
| APOE ε4-carrier | 0.18 (0.012) | 0.078 | 0.02 (0.13) | 0.853 | −0.03 (0.013) | 0.799 |
| R 2 | 0.20 | 0.28 | ||||
Whole brain volume as the independent variable.
Values in bold are significant. β: coefficient; SE: standard error; R2: explained variance; NQ: NeuroQuant®; MMSE-NR: Mini-Mental State-Examination Norwegian revision.