Table 4.

Longitudinal associations between GSLTPAQ scores and concurrent changes in QoL metrics as measured by FACIT Fatigue or Dyspnea over time^*

		Change in QoL measure in breast cancer, according to physical activity (n = 80)		Change in QoL measure in lung cancer and lymphoma, according to physical activity (n = 50)
Physical activity measure	QoL measure	β-coefficient (95% CI)†	P value	β-coefficient (95% CI)†	P value
Overall GSLTPAQ score
	FACIT Fatigue score	1.6 (1.0–2.3)	<.001	1.3 (0.5–2.1)	.001
	FACIT Dyspnea score	−0.9 (−1.3 to −0.4)	<.001	−0.6 (−1.0 to −0.2)	.003
GSLTPAQ MVPA score
	FACIT Fatigue score	1.8 (1.1–2.4)	<.001	1.3 (0.4–2.1)	.003
	FACIT Dyspnea score	−0.8 (−1.3 to −0.4)	<.001	−0.6 (−1.1 to −0.2)	.004

Abbreviations: CI = confidence interval; FACIT = Functional Assessment of Chronic Illness Therapy; GSLTPAQ = Godin—Shephard Leisure-Time Physical Activity Questionnaire; MVPA = moderate-to-vigorous physical activity; QoL = quality of life.

^*Generalized estimating equation linear regression modeled the concurrent association between QoL and physical activity scores over time, both before and after radiation therapy. Models were adjusted for age, sex (in lung cancer and lymphoma only), mean heart dose, radiation therapy duration, chemotherapy exposure (none, preceding, or concurrent), and the time point of assessment. Note that higher overall GSLTPAQ and GSLTPAQ MVPA scores indicate greater physical activity, higher FACIT fatigue scores indicate less fatigue, and higher FACIT dyspnea scores indicate worse dyspnea.

^†β-coefficients represent the concurrent difference in each QoL outcome measure for every 10-point increase in overall GSLTPAQ and GSLTPAQ MVPA scores at each time point.