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Map of the D4R gene regions in wt vaccinia virus (WR-wt) and in the defective viruses vD4-vA and vD4-prME. In vD4-vA, the D4R ORF is partially substituted by a 400-bp DNA fragment of phage φX. In vD4-prME, the substitution comprises the TBE virus prM/E, lacZ, and gpt ORFs. The direction of transcription is indicated by arrows.
