Table 3.

Most common adverse reactions in at least 10% of patients (N=97)

Body System Organ Class AE	All Grades (%)	Grades 3 - 5 (Max Grade) (%)
Blood and lymphatic system disorders
Coagulopathy*	22	2
Febrile neutropenia	10	9
Cardiac disorders
Tachycardia *	27	1
Gastrointestinal disorders
Diarrhea*	33	1
Nausea	31	1
Constipation	22	0
Vomiting	20	0
General disorders & administration site conditions
Pyrexia	96	5
Fatigue *	47	7
Chills	33	0
Edema*	23	0
Immune system disorders
Cytokine Release Syndrome*	95	5
Hypogammaglobulinemia *	93	2
Infections and infestations*
Infections: pathogen unspecified*	41	19
Upper respiratory tract infection*	28	3
Viral infections*	23	7
Pneumonia *	14	13
Sepsis*	10	7
Metabolism and nutrition disorders
Decreased appetite	29	1
Musculoskeletal and connective tissue disorders
Musculoskeletal pain*	48	2
Nervous system disorders
Encephalopathy*	30	6
Headache	27	0
Dizziness*	23	1
Motor dysfunction *	16	3
Psychiatric disorders
Insomnia*	13	0
Respiratory, thoracic and mediastinal disorders
Cough*	39	0
Dyspnea*	23	3
Nasal congestion	15	0
Hypoxia	12	4
Vascular disorders
Hypotension*	51	10
Hypertension	19	6
Hemorrhage*	16	4

^*Includes group terms. Refer to prescribing information for definitions.

Data from source: Prescribing information of ciltacabtagene autoleucel ⁶