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. 2024 May 23;416(18):4015–4028. doi: 10.1007/s00216-024-05339-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — PI 38:3 intensity positively correlates with Ki67⁺ CD45⁻ CD3⁻ cells in ccRCC biopsies. a Ion image of m/z 887.5620 (PI 38:3) of case RN 211 and selected regions of interest (ROI) of high (H1) and low (L1) ion intensity. b H&E-stained section post-DESI-MSI highlighting ROI of high (H1) and low (L1) PI 38:3. c Composite image of mIF labelling, post-DESI and H&E staining, of Ki67⁺ (green), CD45⁺ (yellow), and CD3⁺ (red) cells and image analysis results of the ROI of high and low PI 38:3 highlighting in green Ki67⁺ CD45⁻ CD3⁻ cells. d m/z 887.5620 ion intensity of the analyzed ROI. e Percentage of positive cells for each analyzed phenotype amongst the total number of cells in the ROIs. f Logarithmic positive correlation of PI 38:3 average intensity with Ki67⁺ CD45⁻ CD3.⁻ cells in the analyzed ROI (two-tailed Spearman’s correlation analysis r = 0 0.93, p = 0.0007)