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. 2024 Jun 15;16(3):28–54. doi: 10.62347/RTMH4490

Figure 9.

Figure 9

Immunofluorescence intensity profiling and loci of the AJ-nGJ complex at mossy fiber terminals on CA3 pyramidal cell dendrites. (A) Line profile of immunofluorescence labelling of Cx36 and nectin-1 at mossy fiber terminals in the ventral hippocampus of adult rat, with line tracking through several Cx36-puncta. (B) Histogram of immunofluorescence intensity along the white line in (A), showing overlap or close spatial proximity of peak labelling intensity for Cx36-puncta and nectin-1. (C) Schematic diagram illustrating locations of the components for mixed synaptic neurotransmission from mossy fiber terminals to CA3 pyramidal cell dendrites. The chemical synapse component is localized on the spine head at active zones and the electrical component consisting of Cx36-containing gap junctions closely associated with adherens junctions at the AJ-nGJ complex is localized at contacts between the mossy fiber terminal and dendritic shaft of the CA3 pyramidal cell.

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