Table 1.

Appropriate use of PPI in adults and children

Appropriate indications of PPI in adults	Appropriate indications of PPI in children
Healing of EE and maintenance to prevent relapse	Pathologic reflux symptoms in children >1 year
PPI-responsive eosinophilic esophagitis	Peptic ulcer disease
Peptic ulcer disease	Eosinophilic esophagitis
GERD	H. pylori eradication
Relief of symptoms in patients with NERD
Barrett's esophagus
Zollinger-Ellison syndrome
Short-term treatment of functional dyspepsia
Eradication of H. pylori infection
Prophylaxis and healing of NSAID-associated gastric ulcers, and prophylaxis of gastrointestinal side effects of antiplatelet or anticoagulant therapy in high-risk patients.
SUP in critically ill patients at risk

GERD, gastroesophageal reflux disease; NERD, non-erosive reflux disease; PPIs, proton pump inhibitors; SUP, stress ulcers prophylaxis