Table 2.

Inappropriate use of PPIs in children and adults

Inappropriate indications of PPI
Routine use in patients with mild, infrequent heartburn
Non-specific upper abdominal discomfort without a confirmed diagnosis
Long-term use without reevaluation
Routine prophylactic use with primary care treatment of non-ulcerogenic nature
Routine prophylactic use with NSAIDs and antibiotics
Routine prophylactic use with antiplatelet therapy in low-risk patients
SUP in low-risk, non-ICU hospitalized patients
Management of extra-esophageal symptoms

ICU, intensive care unit; NSAIDs, non-steroidal anti-inflammatory drugs; SUP, stress ulcer prophylaxis