Table 5.
Univariable and Multivariable Logistic Regression Analyses of Objective Response
| Variable | Univariable analysis | Multivariable analysis | |||
|---|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | ||
| Age, yr | 1.02 (0.97–1.06) | 0.439 | |||
| Male sex | 0.79 (0.25–2.46) | 0.688 | |||
| BCLC stage | 0.898 | ||||
| B | Reference | ||||
| C | 1.09 (0.30–3.89) | ||||
| ALBI grade | 0.103 | 0.074 | |||
| 1 | Reference | Reference | |||
| 2 | 0.42 (0.15–1.19) | 0.30 (0.08–1.13) | |||
| NLR | 0.417 | ||||
| ≤4.0 | Reference | ||||
| >4.0 | 1.58 (0.52–4.74) | ||||
| CRAFITY score | |||||
| 0 | Reference | ||||
| 1 | 0.54 (0.18–1.62) | 0.269 | |||
| 2 | 0.28 (0.05–1.59) | 0.151 | |||
| Etiology | |||||
| Non-viral | Reference | ||||
| Viral | 2.71 (0.55–13.34) | 0.219 | |||
| Prior local treatment | 1.23 (0.38–3.96) | 0.727 | |||
| Macrovascular invasion | 0.74 (0.23–2.37) | 0.615 | |||
| Bile duct invasion | 0.85 (0.08–8.66) | 0.891 | |||
| Liver infiltration >50% | NA | 0.993 | |||
| Lung metastasis | 0.31 (0.08–1.18) | 0.085 | |||
| LN metastasis | 1.58 (0.52–4.74) | 0.417 | |||
| Bone metastasis | 1.56 (0.49–4.96) | 0.448 | |||
| Peritoneal seeding | 21.22 (2.36–190.01) | 0.006 | 20.53 (2.11–198.72) | 0.009 | |
| Combined RT | 5.00 (1.24–20.14) | 0.023 | 9.86 (1.90–51.10) | 0.006 | |
HR, hazard ratio; CI, confidence interval; BCLC, Barcelona Liver Cancer; ALBI, albumin-bilirubin; NLR, neutrophil-to-lymphocyte ratio; CRAFITY, C-reactive protein and α-fetoprotein in immunotherapy; LN, lymph node; RT, radiotherapy; NA, not available.