TABLE 3.
Relationships between general characteristics, perioperative and postoperative variables and airway dehiscence during the first year after LT.
| Variables | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|
| Overall population (n = 253) | No airway dehiscence (n = 211) | Airway dehiscence (n = 42) | p-value | Odd-ratio | 95% CI | p-value | |
| Age, years, median [IQR] | 57 [50, 62] | 57 [50, 62] | 58 [52, 62] | 0.670 | |||
| Male sex, n (%) | 162 (64) | 129 (61) | 33 (79) | 0.032 | 2.03 | [0.90–4.97] | 0.102 |
| BMI (kg/m2), median [IQR] | 24.0 [20.0, 27.0] | 24.0 [20.0, 27.0] | 25.0 [23.0, 28.0] | 0.066 | 0.14 | [0.01–0.76] | 0.067 |
| Diabetes mellitus, n (%) | 26 (10) | 22 (10) | 4 (9.5) | >0.999 | |||
| Chronic coronary disease, n (%) | 10 (4.0) | 9 (4.3) | 1 (2.4) | >0.999 | |||
| Mean pulmonary artery pressure (mmHg), median [IQR] | 25 [20, 30] | 25 [21, 30] | 25 [19, 35] | 0.514 | |||
| Need of preoperative ECMO, n (%) | 19 (7.5) | 16 (7.6) | 3 (7.1) | >0.999 | |||
| COPD/emphysema, n (%) | 91 (36) | 75 (36) | 16 (38) | 0.753 | |||
| Pulmonary fibrosis, n (%) | 122 (48) | 99 (47) | 23 (55) | 0.353 | |||
| Double LT, n (%) | 173 (68) | 142 (67) | 31 (74) | 0.407 | |||
| Need of peroperative ECMO, n (%) | 178 (70) | 145 (69) | 33 (79) | 0.202 | |||
| Peroperative transfusion ≥2 RBC, n (%) | 122 (48) | 103 (49) | 19 (45) | 0.672 | |||
| Daytime LT, n (%) | 168 (66) | 132 (62) | 36 (86) | 0.004 | 4.65 | [1.77–15.13] | 0.004 |
| length of total operative time, hours, median [IQR] | 7.20 [6h30, 8h50] | 7h30 [6h30, 8h50] | 7h05 [6h22, 8h10] | 0.393 | |||
| SOFA on ICU admission, median [IQR] | 7.0 [6.0, 9.0] | 7.0 [6.0, 9.0] | 7.5 [6.0, 9.75] | 0.278 | |||
| Duration of vasopressor agent administration, days, median [IQR] | 2.0 [1.0, 4.0] | 1.0 [1.0, 3.0] | 3.0 [2.0, 9.5] | <0.001 | 1.10 | [1.03–1.19] | 0.007 |
| Need of ECMO support during ICU stay, n (%) | 73 (29) | 56 (27) | 17 (40) | 0.069 | |||
| Stage III PGD, n (%) | 48 (19) | 33 (16) | 15 (36) | 0.002 | |||
| Acute kidney injury, KDIGO stage 3, n (%) | 36 (14) | 29 (14) | 7 (17) | 0.621 | |||
Continuous variables are expressed as medians and interquartile ranges (IQRs) and were compared using the Mann‒Whitney U test. Categorical variables are expressed as n (%) and were compared with Fisher’s exact test. BMI, body mass index; ECMO, extracorporeal membrane oxygenation; KDIGO, kidney disease improving global outcomes; MV, mechanical ventilation; PGD, primary graft dysfunction; LT, lung transplantation; SOFA, sepsis-related organ failure assessment; ICU, intensive care unit. The bold values are statistically significant.