Table 5. Regression of log-transform coefficient of variation of nodule volume by nodule characteristics for algorithm #2.

Nodule characteristics	Univariate				Multivariable (Model 1)				Multivariable (Model 2)
	Estimate (β)	Std. error	P value		Estimate (β)	Std. error	P value		Estimate (β)	Std. error	P value
Volume (mm3)	−0.0007	0.0002	0.0012		−0.0005	0.0002	0.017		–	–	–
Nodule location
Upper/middle lobe	Ref.				Ref.				Ref.
Lower lobe	0.18	0.16	0.26		0.10	0.15	0.50		0.10	0.15	0.49
Blood vessel attachment	−0.48	0.15	0.002		−0.37	0.16	0.02		−0.27	0.16	0.09
Costal pleural attachment	0.34	0.28	0.23		0.25	0.27	0.35		0.34	0.26	0.20
Log (nodule surface area)	−0.75	0.17	<0.0001		–	–	–		−0.48	0.14	0.001

Reference category were absent of blood vessel attachment and absent of costal pleural attachment. Std., standard.