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. 2024 Jun 10;56(7):1371–1376. doi: 10.1038/s41588-024-01787-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — For each filter, the number of samples retained after applying the filter is shown. First, samples of broad European ancestry were retained, then samples were excluded in case of low call rate (<0.9), outlying heterozygosity rate (F < − 0.1 or F > 0.1), genetically predicted sex that did not match reported sex, a deviant number of SNVs, INDELs, singletons or outlying Ti/Tv or SNV/INDEL ratio, ≤2^nd degree relatedness (one of each pair is kept) or outlying values on the first five principal components.