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. 2024 Jun 10;56(7):1371–1376. doi: 10.1038/s41588-024-01787-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — a,b, Projection of all samples onto PCA coordinates of a reference ancestry space comprising 1000 Genomes samples. Grey dots indicate the 81,507 samples included in this study. Colored dots indicate the 1000 Genomes samples, colored by superpopulation label, onto which the study samples were projected. c, Sample call-rate distribution. Samples with a call-rate < 0.9 were excluded. d, Heterozygosity. Samples with F < − 0.1 or F > 0.1 were excluded. e, X-chromosome homozygosity. Samples with ambiguous sex (0.4 < F < 0.6) or where genetically predicted sex did not match reported sex were excluded (F < 0.4 = female; F > 0.6 = male). f, Principal component analysis (PCA). A distinct cluster was identified on the fifth principal component, samples with PC5 < −0.02 were excluded. g, Total variant count distributions. Samples were excluded if nSNV > 4000, nINDEL > 400, nSNV (Singletons) > 250, nINDEL (Singletons) > 100, Ti/Tv ratio < 2.4 or > 3.7 or INDEL/SNV ratio > 0.165.