Table 2.

Previous honey applications in wound dressings.

Wound dressing	Targets	Methodologies	Results	References
MedihoneyTM (A honey‐colloid dressing with a proprietary blend of honey applied to a sterile dressing pad with approximately 20 g of honey per application)	40 patients with non‐healing leg ulcers	It was a 12‐week study. The wounds were assessed using Doppler ultrasound and measured through digital imaging, subsequently evaluated fortnightly. Questionnaires were employed to gauge their self‐reported pain levels and the presence of odor after Medihoney treatment.	50% of the patients experienced a reduction in reported pain levels. Among the 26 patients with malodorous wounds, all experienced a significant decrease in the average overall odor level, with 11 patients noting the absence of any remaining odor. Additionally, there was a noteworthy reduction in the size of the wounds in 20 patients' ulcers.	[30]
MedihoneyTM (Medihoney Antibacterial Wound Gel)	8 patients with surgical leg wounds	The wound progress was monitored over 1−2 months by measuring the wound size and self‐evaluating the pain, exudate, and malodor levels.	The results showed a significant reduction in wound sizes, with some achieving complete healing. The surgical wounds had a notable decrease in odor, pain, and exudate. Almost all patients exhibited 100% wound granulation or epithelialization, indicating nearly complete healing of the wounds.	[31]