TABLE 1.

Immunization schedule, dose, and antibody endpoint binding titers against homologous and cross-subtype monomeric rgp120 and V3 peptides

Baboon	Immunogen	Dose (μg); schedule (mo)	Serum antibody endpoint binding titer (ELISA)a
			rgp120		V3 peptide
			SF2	CM235	SF2	CM235
Clade B
B54	rgp120SF2/MF-59	50; 0, 1, 2, 6	51,200	51,200	6,400	<100
B55	rgp120SF2/MF-59	50; 0, 1, 2, 6	204,800	51,200	51,200	<100
B56	rgp120SF2/MF-59	50; 0, 1, 2, 6	51,200	12,800	25,600	<100
B57	rgp120SF2/MF-59	50; 0, 1, 2, 6	102,400	12,800	ND	<100
B58	rgp120SF2/MF-59	50; 0, 1, 2, 6	25,600	12,800	3,200	<100
Geometric mean			67,600	22,300
Clade E
B62	rgp120CM235/MF-59	50; 0, 1, 6	12,800	102,400	<100	800
B63	rgp120CM235/MF-59	50; 0, 1, 6	12,800	51,200	<100	200
B64	rgp120CM235/MF-59	50; 0, 1, 6	12,800	51,200	<100	400
B65	rgp120CM235/MF-59	50; 0, 1, 6	51,200	409,600	<100	1,600
B66	rgp120CM235/MF-59	50; 0, 1, 6	25,600	102,400	100	1,600
B67	rgp120CM235/MF-59	50; 0, 1, 6	25,600	102,400	<100	800
B68	rgp120CM235/MF-59	50; 0, 1, 6	25,600	409,600	100	400
B69	rgp120CM235/MF-59	50; 0, 1, 6	3,200	12,800	<100	100
B70	rgp120CM235/MF-59	50; 0, 1, 6	25,600	51,200	<100	200
B71	rgp120CM235/MF-59	50; 0, 1, 6	25,600	204,800	<100	3,200
Geometric mean			18,100	95,500

^aAntibody endpoint binding titers of preimmune baboon sera against each of the antigens were <100. ND, not determined.