TABLE 3.
Comparison of linear epitope specificities of SF2- and CM235-immunized baboons
| gp120 region | Total peptidesb | Peptidesa
|
|||
|---|---|---|---|---|---|
| Baboons immunized with SF2
|
Baboons immunized with CM235
|
||||
| SF2 | CM235 | SF2 | CM235 | ||
| C1 | 25 | 58, 90, 102, 106 | 86, 90, 102, 106 | 30, 102 | 30, 102 |
| V1/V2 | 17 | 162, 166, 170, 174 | 170 | — | 166, 170, 174 |
| C2 | 25 | 194, 266, 274, 278 | 262, 266 | — | 202, 234, 266 |
| V3 | 9 | 302, 306, 310, 314 | 306, 310 | 306 | 306, 310, 314 |
| C3 | 17 | 334, 338, 342, 354, 358, 370, 386 | — | — | — |
| V4 | 5 | 394, 406 | — | — | — |
| C4 | 11 | 410, 414, 430, 434, 442 | — | 430 | — |
| V5 | 3 | 462 | — | — | 462, 466 |
| C5 | 11 | 470, 474, 478, 482, 486, 494, 498 | 470, 474, 478, 482, 486 | 470, 474, 478, 498 | 470, 474, 494, 498 |
| Totalc | 123 | 38 | 14 | 8 | 17 |
a
Peptides to which at least 40% of baboon sera from each vaccine group are reactive, represented by the starting amino acid number for each 12-amino-acid-length peptide. —, no peptide recognized in the region.
b
Total number of peptides contained in each of the gp120 regions and screened for serum reactivity.
c
Total number of reactive peptides for each baboon group.