Table 2.

Diagnostic criteria for patients presenting with possible FPIES: Chronic FPIES

Milder	Intermittent vomiting and/or diarrhea occurs with regular ingestion of the food trigger; the patient presents with poor weight gain and/or failure to thrive, without dehydration or metabolic acidosis
Severe	Intermittent vomiting and diarrhea (with or without blood) occurs with regular ingestion of the food; the patient may also present with poor weight gain and/or failure to thrive; the patient may develop dehydration and metabolic acidosis
Important Criterion	The resolution of symptoms can occur within days to weeks of discontinuing the food trigger(s); reintroduction of the food trigger(s) will lead to acute symptoms (vomiting in 1–4 hr, diarrhea within 24 hr); the diagnosis of chronic FPIES is confirmed by food challenge

FPIES = Food protein–induced enterocolitis syndrome.

^*Adapted with permission from Ref. 1.