. 2020 Sep 1;2(1):48–54. doi: 10.2500/jfa.2020.2.200011

Table 4.

Diagnostic criteria for interpretation of OFCs in patients presenting with history of possible or confirmed FPIES

	Major Criterion (1)	Minor Criteria (≥2)
FPIES OFC	Vomiting 1–4 hr after ingestion of food (absence of classic IgE-mediated allergic skin or respiratory symptoms)	Lethargy
		Pallor
		Diarrhea in 24h (usually 5–10h)
		Hypotension
Diagnosis for positive OFC^*: 1 Major and ≥2 Minor criteria		Hypothermia
Diagnosis for positive OFC^*: 1 Major and ≥2 Minor criteria		Increased neutrophil count of ≥1500 neutrophils above the baseline count

OFC = Oral food challenge; FPIES = food protein–induced enterocolitis syndrome; IgE = immunoglobulin E.

Adapted with permission from Ref. 1.