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. 2024 Jul 1;15:1409448. doi: 10.3389/fimmu.2024.1409448

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Copyright © 2024 Mao, Gao, Long, Guo, Chen, Huan and Yin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Spatial transcriptomic analysis reveals PDGFRB signaling and Genomic Alterations in HCC. (A) VEGFA/FLT1_KDR, VEGFB/FLT1_KDR, VEGFC/FLT4_KDR, PDGFA/PDGFRA_PDGFRB, PDGFB/PDGFRA_PDGFRB, PDGFC/PDGFRA, PDGFD/PDGFRB signaling direction in human liver cancer tissue. (B) OS of PDGFRB CNV in TCGA LIHC. (C) Heterozygous amplification and deletion of specific genes CNV in TCGA LIHC. (D) Identification of the differentially expressed genes due to the total amount of received signal in the Mitotic signaling pathway. (E) The level of FGL1 received signal. (F) Vector fields consisting of the aligned gradients of spatial shifts in gene-expression levels.