Table 2.
The top 10 functional annotations (GO) Pathways for significantly up- and down-regulated proteins in the distal compared to the proximal nerve end after an injury in 26 human injured digital nerves repaired within 48 h post-injury.
| Increased abundance in distal nerve end | Count | p value | Decreased abundance in distal nerve end | Count | p value |
|---|---|---|---|---|---|
| Biological process | |||||
| GO:0044699 single-organism process | 30 | 0.015 | GO:0051179 localization | 48 | 0.002 |
| GO:0032502 developmental process | 18 | 0.020 | GO:0044763 single-organism cellular process | 73 | 0.003 |
| GO:0048856 anatomical structure development | 17 | 0.020 | GO:0009987 cellular process | 94 | 0.003 |
| GO:0006810 transport | 16 | 0.004 | GO:0048518 positive regulation of biological process | 46 | 0.006 |
| GO:0051234 establishment of localization | 16 | 0.007 | GO:0044699 single-organism process | 83 | 0.009 |
| GO:0044765 single-organism transport | 14 | 5.41E-4 | GO:0048522 positive regulation of cellular process | 40 | 0.022 |
| GO:1902578 single-organism localization | 14 | 9.81E-4 | GO:0048519 negative regulation of biological process | 40 | 0.028 |
| GO:0006928 movement of cell or subcellular component | 11 | 0.003 | GO:0050896 response to stimulus | 57 | 0.037 |
| GO:1901564 organonitrogen compound metabolic process | 11 | 0.015 | GO:0071840 cellular component organization or biogenesis | 57 | 2.22E-5 |
| GO:0051649 establishment of localization in cell | 10 | 0.010 | GO:0016043 cellular component organization | 57 | 8.15E-6 |
| Cellular component | |||||
| GO:0097458 neuron part | 11 | 4.49E-4 | GO:0031982 vesicle | 50 | 1.05E-11 |
| GO:0044444 cytoplasmic part | 28 | 3.01E-4 | GO:0044422 organelle part | 75 | 1.12E-6 |
| GO:0044421 extracellular region part | 12 | 0.042 | GO:0005737 cytoplasm | 79 | 1.58E-6 |
| GO:0005576 extracellular region | 14 | 0.030 | GO:0044446 intracellular organelle part | 75 | 2.32E-7 |
| GO:0031982 vesicle | 13 | 0.028 | GO:0012505 endomembrane system | 50 | 2.53E-9 |
| GO:0005829 cytosol | 16 | 0.021 | GO:0005829 cytosol | 45 | 3.80E-5 |
| GO:0005737 cytoplasm | 29 | 0.003 | GO:0016020 membrane | 67 | 5.46E-5 |
| GO:0043230 extracellular organelle | 11 | 0.003 | GO:0044444 cytoplasmic part | 74 | 6.60E-8 |
| GO:1903561 extracellular vesicle | 11 | 0.003 | GO:0043226 organelle | 87 | 9.10E-6 |
| GO:0070062 extracellular exosome | 11 | 0.002 | GO:0043227 membrane-bounded organelle | 83 | 9.70E-6 |
| Molecular function | |||||
| GO:0005515 protein binding | 31 | 0.009 | GO:0005488 binding | 93 | 0.001 |
| GO:0036094 small molecule binding | 11 | 0.010 | GO:0003723 RNA binding | 21 | 0.002 |
| GO:000016 nucleotide binding | 10 | 0.010 | GO:0019899 enzyme binding | 20 | 0.010 |
| GO:1901265 nucleoside phosphate binding | 10 | 0.010 | GO:0036094 small molecule binding | 21 | 0.030 |
| GO:0035639 purine ribonucleoside triphosphate binding | 9 | 0.012 | GO:0097367 carbohydrate derivative binding | 19 | 0.036 |
| GO:0032555 purine ribonucleotide binding | 9 | 0.014 | GO:0005102 receptor binding | 15 | 0.053 |
| GO:0017076 purine nucleotide binding | 9 | 0.014 | GO:0044877 macromolecular complex binding | 19 | 1.08E-4 |
| GO:0032553 ribonucleotide binding | 9 | 0.014 | GO:0005515 protein binding | 92 | 2.97E-9 |
| GO:0097367 carbohydrate derivative binding | 13 | 2.64E-4 | GO:0008092 cytoskeletal protein binding | 15 | 5.98E-4 |
| GO:0043168 anion binding | 14 | 6.75E-4 | GO:0043168 anion binding | 28 | 9.24E-4 |