. 2024 Jul 15;8:73. doi: 10.1186/s41687-024-00751-7

Table 1.

Pearson correlations between the SD NRS and SSD-derived sleep parameters in the ARCADIA 1 (NCT03985943) and ARCADIA 2 (NCT03989349) trials

Sleep parameter^a	Baseline SD NRS score		Change in SD NRS score from baseline to week 8		Change in SD NRS score from baseline to week 16
Sleep parameter^a	ARCADIA 1	ARCADIA 2	ARCADIA 1	ARCADIA 2	ARCADIA 1	ARCADIA 2
SOL	0.267***	0.338***	0.258***	0.173***	0.248***	0.198***
WASO	0.403***	0.385***	0.445***	0.373***	0.488***	0.276***
TWASO	−0.001	0.056	−0.009	0.051	−0.013	0.056
TWT	0.376***	0.418***	0.390***	0.349***	0.412***	0.320***
TIB	0.007	0.112**	−0.080*	0.013	−0.043	0.006
TST	−0.270***	−0.245***	−0.341***	0.259***	−0.338***	−0.243***
SE	−0.430***	−0.433***	−0.449***	−0.374***	−0.482***	−0.380***
NWASO-AD	0.409***	0.400***	0.487***	0.416***	0.506***	0.378***
WASO-AD	0.460***	0.441***	0.485***	0.426***	0.509***	0.366***
SQR	−0.660***	−0.666***	−0.637***	−0.619***	−0.648***	−0.604***
NDS-AD	–	0.153***	–	0.089*	–	0.097*
NDS-AD nap	0.156***	–	0.083*	–	0.081*	–
NDS-AD doze off	0.111**	–	0.047	–	0.055	–
DS-AD total duration	–	0.115**	–	0.081	–	0.097*
DS-AD total nap duration	0.131***	–	0.062	–	0.105*	–
DS-AD total doze off duration	0.078*	–	0.077*	–	0.103*	–

AD (related to) atopic dermatitis, DS daytime sleepiness, NDS number of times of daytime sleepiness, NWASO number of times of WASO, SE sleep efficiency, SOL sleep onset latency, SQR sleep quality/refresh, TIB time in bed, TST total sleep time, TWASO terminal wakefulness after sleep onset, TWT total awake time, WASO wakefulness after sleep onset

^aSSD-derived sleep parameters were assessed at the same time points as the SD NRS

*p < 0.05, **p < 0.01, ***p < 0.001