Table 3.
Application of scRNA-seq in other types of inner ear cells.
| Main idea | Year | Title | Journal | Species | Method | Data source |
|---|---|---|---|---|---|---|
| Otic vesicle | 2014 | Reconstruction of the Mouse Otocyst and Early Neuroblast Lineage at Single-Cell Resolution | Cell | Mouse | Fluidigm C1 | N.A. |
| 2016 | Single-cell analysis delineates a trajectory toward the human early otic lineage | PNAS | Human | Fluidigm C1 | N.A. | |
| 2018 | Single Cell Transcriptomics Reveal Abnormalities in Neurosensory Patterning of the Chd7 Mutant Mouse Ear | Frontiers in Genetics | Mouse | Fluidigm C1 | N.A. | |
| 2023 | Tbx2 and Tbx3 regulate cell fate progression of the otic vesicle for inner ear development | Developmental Biology | Mouse | 10x Genomics | GSE185172 | |
| 2022 | Early Wnt signaling activation promotes inner ear differentiation via cell caudalization in mouse stem cell-derived organoids | Stem Cells | Mouse | 10x Genomics | GSE180062 | |
| 2022 | Sox8 remodels the cranial ectoderm to generate the ear | PNAS | Chicken | Smart-seq2 | GSE168089 | |
| Greater epithelial ridge | 2021 | Single-Cell RNA Sequencing Analysis Reveals Greater Epithelial Ridge Cells Degeneration During Postnatal Development of Cochlea in Rats | Frontiers in Cell and Developmental Biology | Rat | 10x Genomics | GSE170810 |
| 2022 | Pseudo-Temporal Analysis of Single-Cell RNA Sequencing Reveals Trans-Differentiation Potential of Greater Epithelial Ridge Cells Into Hair Cells During Postnatal Development of Cochlea in Rats | Frontiers in Molecular Neuroscience | Rat | 10x Genomics | GSE195702 | |
| 2021 | Greater epithelial ridge cells are the principal organoid-forming progenitors of the mouse cochlea | Cell Reports | Mouse | Smart-seq2 | GSE162308 | |
| 2022 | Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicates epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals. | eLife | Mouse | 10x Genomics | GSE182202 | |
| 2021 | TUB and ZNF532 Promote the Atoh1-Mediated Hair Cell Regeneration in Mouse Cochleae | Frontiers in Cellular Neuroscience | Mouse | – | – | |
| Stria vascularis | 2022 | Single-cell transcriptomic Atlas of mouse cochlear aging | Protein & Cell | Mouse | 10x Genomics | GSA: CRA004814 |
| 2021 | A cell-type-specific atlas of the inner ear transcriptional response to acoustic trauma | Cell Reports | Mouse | 10x Genomics | GSE168041; GSE167078 | |
| 2020 | Characterization of rare spindle and root cell transcriptional profiles in the stria vascularis of the adult mouse cochlea | Scientific Reports | Mouse | 10x Genomics | GSE152551 | |
| 2019 | Single Cell and Single Nucleus RNA-Seq Reveal Cellular Heterogeneity and Homeostatic Regulatory Networks in Adult Mouse Stria Vascularis | Frontiers in Molecular Neuroscience | Mouse | 10x Genomics | GSE136196 | |
| 2021 | Single-Cell RNA-Seq of Cisplatin-Treated Adult Stria Vascularis Identifies Cell Type-Specific Regulatory Networks and Novel Therapeutic Gene Targets | Frontiers in Molecular Neuroscience | Mouse | 10x Genomics | GSE165662 | |
| 2021 | Identification of Potential Meniere's Disease Targets in the Adult Stria Vascularis | Frontiers in Neurology | Mouse | – | – | |
| 2021 | Utilizing Single Cell RNA-Sequencing to Implicate Cell Types and Therapeutic Targets for SSNHL in the Adult Cochlea | Otology & Neurotology | Mouse | – | – | |
| 2022 | Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss | The American Journal of Human Genetics | Mouse | – | – | |
| Endolymphatic sac | 2017 | Molecular architecture underlying fluid absorption by the developing inner ear | elife | Mouse | Fluidigm C1 | GSE87293 |
| 2022 | SOX9 and SOX10 control fluid homeostasis in the inner ear for hearing through independent and cooperative mechanisms | PNAS | Mouse | Smart-seq2 | GSE131196, GSE139587 |
N.A., not available; SI, supporting information; –, no raw data was produced.