Table 1.
Candidate top 10 plasma proteins identified by PWAS analysis for IBD, UC and CD.
| ID | CHR | PWAS.Z | PWAS.P | PWAS.FDR |
|---|---|---|---|---|
| IBD | ||||
| IL23R | 1 | 13.38 | 8.10E-41 | 1.07E-37 |
| IL12B | 5 | 11.56 | 6.27E-31 | 4.16E-28 |
| MST1 | 3 | − 10.17 | 2.75E-24 | 1.22E-21 |
| TNFSF15 | 9 | − 8.25 | 1.56E-16 | 5.17E-14 |
| STAT3 | 17 | 8.17 | 3.06E-16 | 8.12E-14 |
| C2 | 6 | − 7.93 | 2.19E-15 | 4.84E-13 |
| FCGR2A | 1 | − 7.49 | 6.78E-14 | 1.28E-11 |
| PARK7 | 1 | − 7.06 | 1.69E-12 | 2.80E-10 |
| ERAP2 | 5 | 6.56 | 5.49E-11 | 8.09E-09 |
| FCGR3B | 1 | 5.98 | 2.17E-09 | 2.88E-07 |
| UC | ||||
| HLA-DQA2 | 6 | 7.38 | 1.58E-13 | 2.10E-10 |
| MST1 | 3 | − 6.97 | 3.07E-12 | 2.04E-09 |
| IL23R | 1 | 6.81 | 9.61E-12 | 4.25E-09 |
| FCGR3B | 1 | 6.47 | 9.52E-11 | 3.16E-08 |
| STAT3 | 17 | − 6.07 | 1.27E-09 | 3.37E-07 |
| FCGR3A | 1 | 5.91 | 3.45E-09 | 6.54E-07 |
| AIF1 | 6 | − 5.92 | 3.23E-09 | 6.54E-07 |
| FCGR2A | 1 | 5.66 | 1.47E-08 | 2.44E-06 |
| AGER | 6 | 4.94 | 7.93E-07 | 1.17E-04 |
| MAPKAPK2 | 1 | 4.50 | 6.89E-06 | 9.14E-04 |
| CD | ||||
| IL23R | 1 | 12.69 | 6.84E-37 | 9.07E-34 |
| MST1 | 3 | − 9.21 | 3.41E-20 | 2.26E-17 |
| STAT3 | 17 | − 6.47 | 1.01E-10 | 4.46E-08 |
| C2 | 6 | − 6.21 | 5.39E-10 | 1.43E-07 |
| MICB | 6 | 6.22 | 5.05E-10 | 1.43E-07 |
| IL18R1 | 2 | − 6.15 | 7.57E-10 | 1.67E-07 |
| HINT1 | 5 | − 5.85 | 4.89E-09 | 9.26E-07 |
| PLAU | 10 | 5.65 | 1.59E-08 | 2.64E-06 |
| FLRT3 | 20 | − 5.59 | 2.32E-08 | 3.42E-06 |
| RIPK2 | 8 | − 5.12 | 2.99E-07 | 3.96E-05 |
PWAS, proteome-wide association study; ID: ID for the pQTL strongly associated with IBD/UC/CD; PWAS p-value: p-value for the PWAS association.