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. 2024 Mar 5;49(9):1392–1401. doi: 10.1038/s41386-024-01835-0

Fig. 1. Contextual fear memory persistence rapidly emerges at P21 in WT mice.

Fig. 1

A Diagram of contextual fear memory persistence paradigm used in the present study. B Quantification of the percentage time freezing on testing day of No Shock (n = 7) and Shock (n = 8) mice trained on P15 and tested 7 d later. The Shock group did not exhibit significantly more freezing than the No Shock mice. C Quantification of the percentage time freezing on testing day of No Shock (n = 14) and Shock (n = 15) mice trained on P35 and tested 7 d later. The Shock group exhibited significantly more freezing than No Shock (****p < 0.0001). D Quantification of the percentage time freezing on testing day of No Shock (n = 6) and Shock (n = 8) mice trained on P20 and tested 7 d later. The Shock group did not exhibit significantly more freezing than the No Shock mice. E Quantification of the percentage time freezing on testing day of No Shock (n = 12) and Shock (n = 13) mice trained on P21 and tested 7 d later. The Shock group exhibited significantly more freezing than No Shock (****p < 0.0001). F Quantification of the percentage time freezing on testing day of No Shock and Shock mice trained at different ages and tested 7 d later (P21 No Shock: n = 12; P21 Shock: n = 13; P22 No Shock: n = 10; P22 Shock: n = 11; P23 No Shock: n = 6; P23 Shock: n = 10; P35 No Shock: n = 14; P35 Shock: n = 15). Shock mice exhibit significantly more freezing than No Shock mice at each (*p < 0.05; **p < 0.01, ****p <0.0001, ns, not significant).