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DNA methylation identified three distinct subtypes of PTPR tumors. a Unsupervised UMAP plot of collected PTPR tumors and in-house RELA fusion positive supratentorial ependymoma (EPN), and pineal parenchymal and retinal tumors (including PPTID-A/B, PB-GRP1A/GRP1B/GRP2, PIN-CYT). b–c UMAP plot (b) and cluster-heatmap (c) of PTPR tumors in this cohort. d boxplot of genomic mean methylation across the three PTPR tumor subtypes
