Table 3.

Differentially expressed proteins among the serum of the subgroups.

Classes	Protein description	Name	Unadjusted P	Benjamini–Hochberg critical value	Effect on autophagy	Functions
Class 1 C > N > R	Leucine-rich alpha-2-glycoprotein	LRG1	0.0001	0.0002*	Enhancement	Promote autophagy via the regulation of the TGF-β-smad1/5 signaling pathway
Class 2 R > C > N	Vitamin-D binding protein	VDB	0.0002	0.0002*	Inhibition	Sequestrates free vitamin D, which enhances autophagy via mTOR inhibition at the induction stage, Beclin 1 and PI3K3 augmentation at the nucleation stage, and activation of lysosome at the maturation and degradation stage
Class 3 R > N > C	C4b-binding protein beta chain	C4BPB	0.0002	0.0002*	Inhibition	C4b-binding protein (C4BP), composed of seven alpha-chains and one beta-chain, is main soluble regulator of complement system Binds with protein S (PS), blocking the site of PS responsible for the effect on phagocytic index
Class 3 R > N > C	C4b-binding protein alpha chain	C4BPA	0.0004	0.0004*

C control, N non-responsive to nilotinib, R responsive to nilotinib.

Unadjusted P valued were derived from the analysis of covariance. Benjamini–Hochberg adjustment was used for the adjustment for the multiple comparison. Benjamini–Hochberg critical value was calculated using the false discovery rate of 0.2

*Statistical significance after Benjamini–Hochberg adjustment.