Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jul 15;22:661. doi: 10.1186/s12967-024-05458-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 3 — Gene-target and protein pathway regulatory networks of the selected miRNA. In silico analysis. A miRNet analysis showing that RORA, ZNF134, ZNF217 and ZNF264 genes were identified as common target of the putative miRNA-regulated pathways according to miRTarBase v8.0 and TarBase v8.0. B Reactome pathway analysis displaying the significant pathways connecting target genes of the dysregulated miRNAs. Legend. Total genes implicated: number of genes annotated in the Reactome; Hits: Number of genes resulting from the miRNet analysis involved in the corresponding pathway; Genes: Genes involved. C RORA protein-protein interacting network performed by STRING analysis. Network representing protein-protein associations (blue interactions are known from curated databases, pink is known experimentally determined, green is text mining and black are co-expression) (See Additional File 5: Figure S3 for more detailed information of each protein in the node). D Table illustrating the logistic probabilities of RORA-miRNA binding for each RORA gene variant (See Additional File 6: Figure S4 for more detailed information of each miRNA seed-gene binding site)