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. 2024 Jul 16;16:91. doi: 10.1186/s13148-024-01709-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Dox treatment upregulated cardiotoxicity-related genes. A Volcano plot showing the expression alteration of genes in rat cardiomyocytes upon Dox treatment. B Histogram showing the number of down-regulated and up-regulated genes with different fold change in cardiomyocytes upon Dox treatment. C Heatmap showing the genes with both increased H3K27ac signal and increased mRNA expression in rat cardiomyocytes upon Dox treatment. D Gene ontology analysis showing the biological processes for the genes with both increased H3K27ac signal and increased mRNA expression in rat cardiomyocytes upon Dox treatment. E The representative genes with both increased H3K27ac signal and increased mRNA expression in cardiomyocytes upon Dox treatment, several genes are reported to be associated with Dox-induced cardiotoxicity including Fas, Bax and Bnip3, other genes are potentially associated with cardiotoxicity. F, G H3K27ac signal nearby Bnip3 and Egr-1 (F) and their mRNA expression (G) in cardiomyocytes upon Dox treatment with two replicates. H Gene ontology analysis showing the biological processes for the upregulated genes in cardiomyocytes from an in vivo model upon Dox treatment (GSE223698). I Expression of apoptotic and cell death associated genes in cells from mouse heart upon Dox treatment for 24 h. J Compared to the Dox group, volcano plot showing the expression alteration of genes in cardiomyocytes upon Dox + C646 treatment. K Compared to the Dox group, the percentages of down-regulated and up-regulated genes after Dox + C646 treatment. L Compared to the Dox group, the percentage of down-regulated and up-regulated genes among Dox_H3K27ac-upregulated genes after Dox + C646 treatment. M Gene ontology analysis showing the biological processes for the Dox_H3K27ac-upregulated genes with decreased mRNA expression in cardiomyocytes upon Dox + C646 treatment