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. Author manuscript; available in PMC: 2024 Jul 16.
Published in final edited form as: Cell Rep. 2024 Jun 7;43(6):114346. doi: 10.1016/j.celrep.2024.114346

Figure 2. Reduced insulin, but not glucagon secretion in all pancreas regions in recent-onset T1D.

Figure 2.

(A–C) Insulin secretion from slices of PH (A), PB (B), and PT (C) from ND, 1AAb+, and T1D shown as absolute amounts (mU/min).

(D–F) Insulin secretion traces from slices of PH (D), PB (E), and PT (F) from ND, 1AAb+, and T1D donors shown as stimulation index (fold of 1G baseline).

(G–I) Quantification of insulin responses to 5.5G (G), 11.1G (H), and KCl (I) stimulation.

(J–L) Glucagon secretion from slices of PH (J), PB (K), and PT (L) from ND, 1AAb+, and T1D shown as absolute amounts (pg/min).

(M–O) Glucagon secretion traces from slices of PH (M), PB (N), and PT (O) from ND, 1AAb+, and T1D donors shown as stimulation index (fold of 5.5G baseline).

(P–S) Quantification of glucagon responses to 1G (P), 11.1G (Q), 1G (R), and KCl (S).

n = 15 ND, 7 1AAb+, and 5 T1D donors with 4 slices/region/donor. Dots represent individual donors shown with mean ± SEM and RM two-way ANOVA of log-transformed data. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.

See also Figures S2 and S3.