Figure 3.

Violin plots representing age at initial presentation of some of the major clinical features. Dot: mean age at onset of symptom, asterisk: median age at onset of symptom. The table displays the proportion (per cent) of patients who exhibited each symptom at the onset of POLG disease or developed each symptom later in the disease course and the number of patients in whom the symptom was present at the last follow‐up. The onset of the different clinical features could appear across the entire lifespan, although most showed a noticeable trend. While ataxia and seizures were common at the presentation of POLG disease, weakness, hepatic disorder and anaemia typically appeared later during the disease course. In general, most of the symptoms outlined persisted at the last follow‐up.