TABLE 2.
Univariable and multivariable analyses showing the association of HBV viral load, and on-treatment risk of HCC
| Variables | Incidence rate (per 100 PYs) | HR | 95% CI (lower) | 95% CI (upper) | p |
|---|---|---|---|---|---|
| Univariable analysis | |||||
| HBV viral load tier (log10 IU/mL) | |||||
| ≥8.00 | 0.10 | 1.00 (reference) | — | — | — |
| ≥7.00 and <8.00 | 0.48 | 4.81 | 2.04 | 11.30 | 0.0004 |
| ≥6.00 and <7.00 | 1.38 | 13.39 | 5.73 | 31.28 | <0.0001 |
| ≥5.00 and <6.00 | 1.17 | 11.20 | 5.44 | 23.05 | <0.0001 |
| Multivariable analysis | |||||
| HBV viral load tier (log10 IU/mL) | |||||
| ≥8.00 | 0.10 | 1.00 (reference) | — | — | — |
| ≥7.00 and <8.00 | 0.48 | 4.04 | 1.68 | 9.73 | 0.002 |
| ≥6.00 and <7.00 | 1.38 | 8.05 | 3.34 | 19.35 | <0.001 |
| ≥5.00 and <6.00 | 1.17 | 6.23 | 3.10 | 12.51 | <0.001 |
| Age, y, per 1-year increase | — | 1.57 | 1.27 | 1.95 | <0.001 |
| Sex | — | ||||
| Female | 1.00 (reference) | — | — | — | |
| Male | 2.19 | 1.35 | 3.56 | 0.002 | |
| Platelet count, ×1000/μL, per 1000/μL increase | — | 0.56 | 0.48 | 0.65 | <0.001 |
| ALT levels, U/La | — | ||||
| <1 × ULN | 1.00 (ref) | — | — | — | |
| ≥1 to <2 × ULN | 1.89 | 1.18 | 3.02 | 0.008 | |
| ≥2 × ULN | 0.86 | 0.53 | 1.40 | 0.55 | |
The multivariable model adjusted for all baseline characteristics except for follow-up time and mPAGE-B score.
a
ALT was adjusted for as a categorical variable, split into the following levels based on ULN (35 U/L for males, 25 U/L for females): <1 × ULN; ≥1 to <2 × ULN; ≥2 × ULN.
Abbreviations: PY, person-year; ULN, upper limit of normal.